The hamsa is a classic symbol of protection in both Judaic and Arabic cultures. The name of the hand-shaped amulet actually comes from the Arabic word for "five," a reference to the five fingers. Sometimes known as a God's Hand, the hamsa usually has an eye depicted in the palm, to help ward off the Evil Eye. I've replaced that here with the Sefirot, the Ten Emanations that represent the various attributes of God and make up the core of Kabbalistic theology. An eleventh Sefirah is sometimes depicted, which I've included here for the sake of design.
The Sefirot are also known as the "Kabbalistic Tree of Life," and this design was originally conceived of for the third annual auction at my synagogue, Congregation Etz Hayim. That auction didn't happen, so instead I made it for a local artists' expo that the synagogue held. Etz Hayim means "Tree of Life"... you get the idea.